a cohort study.  L, Sturkenboom  G, Sundquist A child of first-cousin consanguineous parents is at increased risk of common mood disorders and psychoses.  S, Sekher  J. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), http://www.independent.co.uk/news/uk/home-news/london-borough-child-deaths-redbridge-parents-related-cousins-pakistani-families-council-report-a7741146.html, http://www.who.int/pmnch/media/news/2012/201204_borntoosoon-report.pdf, https://www.nisra.gov.uk/sites/nisra.gov.uk/files/publications/2001-census-results-key-statistics-report-tables.pdf, https://www.nisra.gov.uk/statistics/deprivation/northern-ireland-multiple-deprivation-measure-2010-nimdm2010, Schizophrenia Spectrum and Other Psychotic Disorders, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. a population-based study. Mental health of extremely low birth weight survivors in their 30s. More than one-third (35.8% [93 of 260]) of children of first-cousin consanguineous unions were in receipt of antidepressant or anxiolytic medications compared with just over one-quarter (26.0% [89 412 of 344 183]) of nonrelated offspring.  RJ, Murray This study demonstrates the ability of population-wide data linkage to explore hard-to-reach populations, and we call on other countries with similar large-scale administrative data sources to use their data to explore the effects of consanguinity on offspring. Its caveats concern the information limitations of the data, including prescription data without accompanying diagnosis codes or indication for use. The final data set comprised 363 960 individuals, alive and residing in Northern Ireland in 2014, with full data on all variables. Third, as per the method above, multilevel multivariable regression models were constructed to estimate the likelihood of psychotropic medication use given the degree of parental consanguinity. All CHS data with an HCN were linked to current population-wide data on prescription medication from the Enhanced Prescribing Database (EPD) and death records to investigate the mental health profile of our cohort.  C, Kranz Bickle Graz The risk is closely related to degree of genetic relationship between parents, so risk is more where parents are close relatives. Customize your JAMA Network experience by selecting one or more topics from the list below. [citation needed] Ayurveda states that marriage within the Gotra (father's side) is a consanguineous marriage which can lead to many gestational and genetic problems in the fetus.  F, Solati-Dehkordi Cowley Regression Analysis to Determine Likelihood of Missing HCN Given Neonatal Factors and Consanguinity of Parents, eTable 3. Non-linear relationship between an index of social deprivation, psychiatric admission prevalence and the incidence of psychosis.  ER.  Z, Lichtenstein Consanguineous marriage is a union between couples related as second cousins or closer. Receipt of antidepressant or anxiolytic medications was used as a proxy for common mood disorders, whereas receipt of antipsychotic medications was used as a proxy indicator of psychoses. eTable 4.  BM, Rickert Privacy Policy| study based on primary health care centre visits.